منابع مشابه
Human T cell leukaemia/lymphoma virus and blood donation.
to draw up a severity scale with set treatments for each level. In one such management plan, stopping neuroleptics is not mandatory until fever exceeds a certain threshold.'5 We wait to see the results of such a plan but in the meantime should develop our own. Routine screening ofblood donors is not currently indicated in Britain On p 1235 Brennan and colleagues report that about one in 20 000 ...
متن کاملHuman T-cell leukaemia virus type 1: parasitism and pathogenesis
Human T-cell leukaemia virus type 1 (HTLV-1) causes not only adult T-cell leukaemia-lymphoma (ATL), but also inflammatory diseases including HTLV-1-associated myelopathy/tropical spastic paraparesis. HTLV-1 transmits primarily through cell-to-cell contact, and generates abundant infected cells in the host in order to survive and transmit to a new host. The resulting high proviral load is closel...
متن کاملAdult T-cell leukaemia/lymphoma (ATLL) and T-cell leukemia virus type 1 (HTLV1)
Epidemiology The disease has a long latency, and affected individuals usually are exposed to the virus very early in life. The virus may be transmitted in breast milk, and through exposure to blood and blood products. The cumulative incidence of ATLL is estimated to be 2.5% among HTLV-1 carriers in Japan (1). Sporadic cases have been found in the United State and elsewhere. It occurs in adults ...
متن کاملHairy cell leukaemia with T cell features.
A case of clinically and hematologically typical hairy-cell leukemia has been presented in which, at the various times of testing, 52%-95% of peripheral blood and 73% of splenic mononuclear cells formed spontaneous sheep erythrocyte (E) rosettes. Many of the rosetting cells were shown to be typical morphologic hairy cells by light and electron microscopy. It was found that 70%-75% of peripheral...
متن کاملActivation of hypoxia-inducible factor 1 in human T-cell leukaemia virus type 1-infected cell lines and primary adult T-cell leukaemia cells
HTLV-1 (human T-cell leukaemia virus type 1) is the causative agent for ATL (adult T-cell leukaemia). HTLV-1 Tax can activate the PI3K (phosphoinositide 3-kinase)/Akt signalling pathway, which is responsible for survival of HTLV-1-infected T-cells. HIFs (hypoxia-inducible factors) are transcriptional regulators that play a central role in the response to hypoxia. Overexpression of HIF-1alpha in...
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ژورنال
عنوان ژورنال: Nature
سال: 1990
ISSN: 0028-0836,1476-4687
DOI: 10.1038/344299b0